RESEARCH

Opening up new avenues for the wellbeing and health of all

 

2 PROJECTS TO BE FINANCED IN 2021

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The Scientific Council

An advisory
body

  • discusses where to direct the endowment’s funds and its work programmes before submitting them to the board of directors for approval,
  • offers scientific advice to the board of directors.

An advisory
council body

  • contributes to the scientific activities of the Microbiome Foundation,
  • endorses the documents distributed by the Microbiome Foundation,
  • carries out missions of analysis, evaluation, and scientific foresight assigned by the board of directors.

An advisory
jury

  • evaluates projects received as part of the annual or biannual call for proposals,
  • prioritises the projects selected for funding and presents these to the board of directors along with its opinion,
  • submits the call for proposals to the board of directors for approval.

Members

Our Scientific Council, composed of experts, guarantees the scientific quality of projects selected to receive funding.
It acts as both a jury and advisory board.
Its highly qualified members represent various areas of work on the microbiota.

Dr. Judith ARON-WISNEWSKY, MD, PhD

University lecturer, hospital practitioner in the Department of Nutrition at Pitié-Salpétrière Hospital

Pierre DÉCHELOTTE , MD, PhD

Professor of Nutrition, Director of the INSERM 1073 laboratory “Nutrition, Inflammation, and Gut-Brain Axis Dysfunction”, Chief of the Division of Nutrition, Rouen University Hospital

Pierre DÉCHELOTTE , PhD

Professor of Immunology, Director of the “Microenvironment & Immunity” unit of the Institut Pasteur and INSERM, Director of the Department of Immunology, Institut Pasteur, Paris

Pierre DÉCHELOTTE , MD, PhD

MD, PhD,Chief of the Division of Pediatric Gastroenterology, Hepatology, and Nutrition at Necker-Enfants Malades Hospital

Patricia LEPAGE

Researcher at INRA (French National Institute for Agricultural Research)

Submit a scientific proposal

The Microbiome Foundation supports medical research projects on the gut microbiota – for which a healthy and varied diet is key – in its quest to prevent the development of diseases and to cure them, thanks to very promising new therapeutic approaches.

We fund clinical and fundamental research on the gut microbiota in connection with diseases associated with a disturbance of the microbiota in order to understand the mechanisms (immunity, metabolism, etc.) through which the microbiota acts.

Projects to finance

In 2021, the Microbiome Foundation is supporting two major new projects in the field of gut microbiota:

The Autism and Microbiote Project, an innovative and promising intestinal microbiota transplant therapy for autism spectrum disorders, which aims to restore the symbiosis between the host and its microbiota.

The French Gut project is part of the major international project called the Million Microbiome of Humans Project (MMHP) and aims to create the world’s largest human microbiota database, analyze 1 million samples and explore the full potential of the microbiome.

The French Gut
Autism and microbiota

The Microbiome Foundation supports an innovative and promising project in the field of autism based on modulation of the intestinal microbiota.

More informations

The French Gut
project

The French Gut Project is a national citizen contribution to microbiome science.
with the ambition of defining the heterogeneity of healthy gut microbiomes within the French population.

More informations

Current projects

A) “Gut-liver” interactions in the area of primary sclerosing cholangitis (PSC), a research project at Saint-Antoine Hospital, a referral centre for biliary diseases.

This is Astrid Kemgang’s PhD thesis project, under the direction of Sara Lemoinne (assistant chief resident), Harry Sokol (university professor and hospital practitioner), and Chantal Housset (university professor and hospital practitioner).

Description: PSC is often associated with chronic inflammatory bowel disease (IBD), primarily ulcerative colitis and, to a lesser extent, Crohn’s disease.

Genomic studies have shown that IBD and PSC have a certain number of genetic susceptibility factors in common, while others are specific.

Dysbiosis, a state of disequilibrium of the gut microbiota, has been shown to be present in IBD and PSC. Moreover, the gut microbiota participates in the metabolism of bile acids, which can themselves alter the microbiota. Professor Harry Sokol’s team has shown that dysbiosis associated with IBD provokes changes in the composition of intraluminal bile acids, which are likely involved in the chronic inflammation seen in IBD.

The aim of this research is to study the enterohepatic axis throughout PSC in order to determine the potential impact of colonic disease on hepatic disease and vice versa.

B) Functional gastrointestinal disorders and anxiety disorders in obesity and anorexia nervosa: the role of the gut microbiota, a research project at Rouen University Hospital.

The Microbiome Foundation, thanks to the generosity of the Roquette Foundation for Health (https://fr.roquette.com/la-fondation-roquette-pour-la-sante/), is supporting the research project of Professor Pierre Déchelotte (Professor of Nutrition, Director of the INSERM 1073 laboratory “Nutrition, Inflammation, and Gut-Brain Axis Dysfunction”, Chief of the Division of Nutrition, Rouen University Hospital), which describes the role of the gut microbiota in the appearance and maintenance of functional gastrointestinal disorders frequently observed in anorexia and obesity.

How?

  • Based on a series of animal (mouse) experiments using validated models of obesity and anorexia, stress models that induce digestive and eating disorders, and experiments in transplanting the microbiota of obese/anorexic animals.
  • By studying the composition of the microbiota, the intestinal response (barrier, inflammation, immunity), nutritional status, and central regulation of eating behaviour.
  • By evaluating specific nutritional interventions that target the microbiota in order to reduce digestive disorders and disordered eating behaviours in these same animals.

Why?

To identify potential new nutritional treatments (amino acids, fatty acids, prebiotics, probiotics) that, through their modifying effect on the microbiota, might make it possible to improve the therapeutic care and quality of life of patients with obesity or anorexia. The value of these results will subsequently be enhanced because of their availability to many affected patients.

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