The French Gut is a national contribution on the gut microbiota. His ambition? Map and understand the heterogeneity of French healthy gut microbiota, the factors that impact them, as well as their deviations in chronic diseases. By 2027, collect of 100,000 faecal samples and associated nutritional and clinical.

The French Gut Project

 

The project includes several scientifics axes:

  • Mapping the gut microbiota in France, to better define the composition of healthy gut microbiota and deepen knowledge on the links between microbiota, diet and lifestyle

  • Modelling and predicting changes in gut microbiota associated with disease. Scientists will study the link between gut microbiota and chronic diseases (diabetes, obesity, cancer, etc.), neurodevelopmental disorders (autism, bipolarity, etc.) and neurodegenerative diseases (particularly Parkinson’s disease).

  • Describe the variations in the gut microbiota associated with the presence and development of certain diseases. In particular the link between gut microbiota and functional disorders: irritable bowel syndrome, diabetes, obesity, cancer, Parkinson’s, autism, bipolarity, …

The French Gut will make it possible, based on the scientific knowledge generated, to move towards personalised preventive nutrition. It will open the way to innovative therapies, particularly in the context of chronic diseases which have been increasing steadily and uncontrollably for three generations.

It will also raise awareness among the public, adults and children, about the microbiota and its link with health and food.

The French Gut is a project carried out in partnership with publics institutions and privates actors involved in the field of microbiota. This major project is in line with the One Health concept, one health, and is part of one of the INRAE 2030 strategic objectives, which is to promote a global approach to health.

The French Gut consortium currently brings together 4 publics institutions (INRAE, AP-HP, INSERM, Institut Pasteur) and 7 private partners.

An international dimension with the Million Microbiomes from Humans Project (MMHP)

Million Microbiomes for Humans

Officially launched on October 26, 2019 at the 14th International Conference on Genomics (ICG-14)

The project in a few details:

  • Analyze 1 million microbial samples from the intestines, mouth, skin, reproductive system…
  • Draw a map of the microbiota of the human body,
  • Build the world’s largest database of human microbiota,
  • A solid database for microbiota research,
  • Explore the potential of the microbiota to help people live better lives.

MetaGenoPolis-INRAE is one of the founders of the MMHP project https://db.cngb.org/mmhp/ and participates in the MMHP by contributing 100,000 French intestinal metagenomes.

International Microbiota Research Program:

• Karolinska Institute of Sweden
• Shanghai National Clinical Research Center for Metabolic Diseases in China
• University of Copenhagen, Denmark
• Technical University of Denmark
• MetaGenoPolis at the National Research Institute for Agriculture, Food and the Environment (INRAE), France
• Latvian Center for Biomedical Research and Studies
• BGI Shenzhen Research
• but also other countries join the project: Latvia, the Netherlands, Germany, Spain, Finland, Norway, Estonia.

Projet Le French Gut